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The spatial separation of treatments in the PCA plot supports these views

J Clin Endocrinol Metab (1985) 61(3):4729

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Fast injection creates turbulence

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Many melanocytomas arise within a preexisting nevus, due to the acquisition of a secondary pathogenic mutation in a single melanocyte which leads to subclonal outgrowth and distinct histopathologic features resulting in a so-called combined nevus