Moreover, the association observed in some epidemiological studies could be sustained by the fact that T2DM and TC could share some common risk factors, such as obesity and increasing age (Kitahara et al., 2020), and TC is often diagnosed incidentally in patients with T2DM due to the performance of screening imaging (such as carotid artery ultrasound), potentially leading to a selection bias ( The second reason why anti-diabetic drugs could be beneficial in TC is that TC cells often display abnormal metabolic pathways that could be sensitive to the specific action of anti-diabetic drugs
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FDAs introductory briefing document states that the agency does not intend to issue a final determination until it has considered input from the advisory committee process and finalized its reviews
This request is sent to the VA Pharmacy, and reviews must be completed within 96 hours, resulting in approval or denial, Fitzgerald says
These findings suggest a wide safety margin, though absence of long-term human data represents a significant gap
