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After reconstitution, the solution must be refrigerated at 2-8 degrees Celsius (35.6-46.4 degrees Fahrenheit)

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At 6 months, patients who discontinued treatment within 0-3 months had a -1.8% weight change, while those persistent for 12 months saw an -8.1% change

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Clinical trial data shows retatrutide produces approximately 28.7% weight loss at the highest dose compared to 22.5% for tirzepatide