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While imaging cannot exclude all forms of the disease, it plays an increasingly important role in supporting a presumptive clinical diagnosis and guiding management without immediate surgical confirmation

Emerging nanotechnology approaches, including polymeric nanoparticles and lipid-based delivery systems, show promise in enhancing SFN stability, prolonging circulation time, and improving tumor-specific delivery (94, 102)

Data were statistically analyzed using GraphPad Prism 10.3.0 software (GraphPad Software Inc., CA, USA)

Melanotan II is generally discussed in the same research lane as alpha-MSH analogs and melanocortin receptor signaling literature [6] [7]

DOI: 10.1007/s00441-019-03016-8

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