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Depletion of cystine/cysteine reduces intracellular GSH levels and GPX4 activity within the cystine/cysteine-GSH-GPX4 axis, thus causing ferroptosis (18,99)
High levels (over 15 micromol/L) and low levels (below 5 micromol/L) are affected by factors like diet, exercise, medications, age, sex, and health
Jansson, J
27 Also, fasting (by shunting acetaminophen metabolism away from glucuronidation or by depletion of intracellular GSH) and chronic ethanol use (via intracellular GSH depletion) can increase susceptibility to acetaminophen hepatotoxicity
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