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Human clinical trials are ongoing, showing, so far, good safety and tolerability

If so, the receptors would continue to be resistant to the natural calming actions of GABA (See Chapter I), and the effect could be to prolong the state of nervous system hyperexcitability

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Skin Pharmacology and Physiology 25(3):141-151. [doi.org]

Upon reaching the liver, the bilirubin albumin complex dissociates, and bilirubin is taken up by hepatocytes through passive diffusion and carrier-mediated mechanisms [23]

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