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The body responds to calorie restriction by tapping stored energy

Insulin secretes only when blood glucose is elevated, not at baseline

Outcome: Effects of GLP-1-RA on cell properties

Treatment with SUN significantly increased heart weight, cardiac index, and cardiotoxicity enzymatic indices, as well as severe histopathological changes

Thus, while NRF2 clearly participates in determining the balance between ASC self-renewal and activation/differentiation, the exact role it plays is context and stem cell niche dependent

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