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GLP-1RA Liraglutide Semaglutide Efpeglenatide Glucose lowering effect CV system protection effect Kidney protection effect Nonalcoholic fatty liver disease GIP/GLP1 receptor coagonists: tirzepatide Amylin/GLP1 receptor coagonists: CagriSema (cagrilintide+semaglutide) Glucagon/GLP1 receptor coagonists: survodutide GIP/GLP1/glucagon receptor triple coagonists: retatrutide Obesity is a disease that can be treated with targeted pharmacotherapy in addition to lifestyle modification and behavioral interventions

Slow and gradual dose adjustments are key for this group, as they help reduce the risk of gastrointestinal side effects like nausea and vomiting, which could lead to volume depletion

Still avoid high-fat, greasy, or very spicy foods

excretion as metabolites only Apparent population mean clearance of 0.061 L/h The majority of the administered dose is recovered within 480 hours (approximately 20 days) following a single subcutaneous dose in human studies

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Song et al., 2016)