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COMPOUNDED VERSIONS WARNING: The FDA has issued alerts regarding compounded tirzepatide, warning that these custom formulations may lack the safety, consistency, and efficacy of FDA-approved medications

doi: 10.1016/j.cmet.2016.02.019 CrossRef Google Scholar View reference in article 10 SukumarDSchlusselYRiedtCSGordonCStahlTShapsesSA

Changes to the 2 position group can affect nucleic acid stability and affinity, 227 with common modifications including 2-fluoro (2-F), 2-O-methoxyethyl (2-MOE), and 2-O-methyl (2-OMe)

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