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No meaningful systemic effects at normal concentrations

For example, statins have been implicated in directly causing immune-mediated necrotizing myopathy thought to be caused by upregulation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the molecular target of statins, resulting in presentation of highly immunogenic HMGCR peptides by human leukocyte antigens

The protective effect of sulforaphane on dextran sulfate sodium-induced colitis depends on gut microbial and Nrf2-related mechanism

For chronic issues, maintenance may be needed

Anyone considering Epithalon should discuss their full medical history, current medications, and any cancer history with a physician first, since telomere-related interventions warrant careful individual review

1994;20(1 Pt 2):S510