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Cardiovascular effects of glucagon-like peptide 1 receptor agonists: from mechanistic studies in humans to clinical outcomes

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Clinical data on tirzepatide in type 2 diabetesthe SURPASS clinical trial program Early clinical studies with tirzepatide revealed a marked and dose-dependent reduction of HbA1c and further glycemic parameters in patients with T2D in various ethnic cohorts (clinical trials registration numbers NCT03322631, NCT03131687, and NCT03311724) (6668)

The findings were independent of overweight/obesity category at baseline, as seen in this subgroup analysis for the primary endpoint

For individuals carrying extra body fat, insulin resistance often compounds the difficulty of losing weight

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