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This method involves four main steps: isolation by strong cation-exchange SPE, mild derivatization with pentafluorophenyl trifluoromethanesulfonate, chromatographic separation using sequential ion-exchange/reversed-phase (ultra) high-performance liquid chromatography [(U)HPLC], and detection by electrospray ionization MRM-MS
44 de la CuevaM.AntequeraD.Ordoez-GutierrezL.WandosellF.CaminsA.CarroE.et al
Last reviewed: April 2026 Next scheduled review: October 2026 (FY2027 update) Ready to turn this knowledge into a credential
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GHK-Cu GHK-Cu delivers copper ions to lysyl oxidasethe enzyme that cross-links collagen fibers into mechanically mature tissue
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