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337 The choice of hypoglycemic agents for initial monotherapy should be personalized considering the need to reduce MDS-related TOD, such as weight management and comorbidities, as demonstrated above

If pregnant or breast-feeding, please consult a healthcare professional prior to using.

This is most relevant for weight-based peptides like kisspeptin (dosed in mcg/kg) and less relevant for receptor-saturating peptides like BPC-157, where tissue concentration at the injury site matters more than total body distribution

Study design should reflect that gap

10.1016/j.freeradbiomed.2022.06.004 28 IngoldI.BerndtC.SchmittS.DollS.PoschmannG.BudayK.et al (2018)

Another hot topic in AD dilemma is the promising role of lactate level in astrocytes and its possible effect on reinstating cognitive decline of AD