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It is considered the master antioxidant due to its role in recycling other antioxidants such as Vitamins C and E and through its direct and indirect (enzymic) neutralization of free radicals such as reactive oxygen species (ROS)

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The susceptibility of cochlear cells to cytostatic agents varies depending on age, genetic factors, and concurrent use of other ototoxic drugs

In comparison to ferroptosis-resistant cells, cells sensitive to ferroptosis accompanied by RAS mutation exhibit elevated TFR1 expression and reduced ferritin expression, indicating that higher iron import and lower iron storage may lead to ferroptosis (Yang and Stockwell, 2008)

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