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Certain natural plant compounds have been shown to support GLP-1 production in lab and animal studies: Flavonoids like (-)-epicatechin (found in dark chocolate) and anthocyanins (from berries and purple veggies) have been shown to increase GLP-1 and improve metabolism via the PKA signaling pathway (Cremonini et al., 2021)

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In relation to these broad drivers for CVD, GLP-1 can mitigate metabolic stressors by curbing excess nutrient intake through the promotion of satiety, weight loss, and reducing hyperglycemia and lipid levels [3,4,5]

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PMID: 11014225

Another phase 2 trial using a higher dose of mazdutide for obesity (9 mg) is currently ongoing with a press release revealing a placebo-adjusted WL of 15.4% after 24 weeks [71]