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Furthermore, exendin-4 can stimulate the cyclic adenosine monophosphate/protein kinase A (cAMP-PKA) pathway by activating GLP-1R, which then increases the level of non-phosphorylated -catenin to stimulate the Wnt/-catenin/NeuroD1 pathway and inhibits the activity of GSK-3, ultimately decreasing the hyperphosphorylation of AD-associated tau proteins regulated by GSK-3 (Reich and Hlscher, 2022)

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P., Radavelli-Bagatini, S., Khn, T., & Wagner, K.-H

Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors

Nov 3 2007;370(9598):1560-7

The abnormal nail plate associated with pigment A nail plate that is structurally altered presents a different scenario