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Recent studies indicate that natural compounds (e.g., resveratrol, curcumin) improve gut-liver barrier function through microbiotaSIRT1 interactions, while synthetic activators (SRT1720) and NAD + precursors (NMN) enhance hepatocyte antioxidant capacity and fatty acid -oxidation

S1PR2, located both in the liver and in the brain, activates the ERK and AKT pathways that regulate cell survival, inflammation, and stress response in the CNS

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SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells