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In both cases, cross-protection was correlated with stronger T-cell responses , particularly NSP12/13 targeting CD8 + T cells [104]

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Studies show it modulates over 4,000 human genes activating those associated with tissue repair and cellular energy, while suppressing genes linked to inflammation and cellular senescence (the "zombie cells" that accumulate in aged tissue and accelerate aging around them)

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227 Endothelial Notch activation induces senescence and SASP in liver sinusoidal endothelial cells, which disrupts liver regeneration

The lung was then inflated using a compressed air source attached to an underwater seal to slowly increase transpulmonary pressure (PL) from 0 to 30 cmH 2 O