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Tirzepatide does not directly alter thyroid hormone production or TSH levels in patients already taking thyroid replacement therapy

J Thyroid Res (2014) 2014:531969.10.1155/2014/531969 80 KlintscharMSchwaigerPMannweilerSRegauerSKleiberM

Medication Interactions and Metabolic Factors Beyond Genetics Even genetically favorable patients may experience semaglutide failure due to drug interactions, thyroid dysfunction, uncontrolled diabetes, or polycystic ovary syndrome

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To determine which metabolic regulator, AMPK or mTORC1, affect MOTS-c expression levels in Min6 -cell lines, we treated the Min6 cells with mTORC1 activator (MHY1485), its inhibitor (rapamycin) and the AMPK activator (AICAR) and its inhibitor (compound C) (Supplementary Fig