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Taking a mathematical modeling and analysis approach allows us to study the relative contribution of each pathway captured in the resulting model

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Interestingly, the top 11 KEGG pathways including diabetic cardiomyopathy, prion disease, thermogenesis, Parkinsons disease, and Alzheimers diseaseshared substantial overlap in upregulated genes with the OXPHOS pathway ( Supplemental Fig

Several endogenous metabolites, including ubiquinol, vitamin E, and vitamin K hydroquinone, function as radical-trapping antioxidants that terminate lipid peroxyl radicals and suppress ferroptotic membrane damage 84-87