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One could speculate that a key treatment strategy for progressive MS could involve targeting CNS-resident B cells, not aiming to suppress their traditional immunological (mis)behavior, but instead to quell a yet-to-be-discovered unconventional action, possibly related to secretion of an MS-specific myelin toxin into the CSF

Although lifestyle changes are the first line of treatment for obesity, even the most rigorous lifestyle changes typically only produce a 510% weight loss and maintaining weight over time is difficult due to compensatory physiological processes that increase appetite and decrease energy expenditure [134]

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[DOI] [PubMed] [Google Scholar] 12.Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M

Its cognitive potential is inferred from TREK-1 knockout mouse phenotypes (enhanced memory) and from neurogenesis data rather than direct cognitive testing

7, July 2023, p