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While both glucocorticoid receptors, GR and MR, regulate leptin expression, GR is the dominant receptor that is involved in cortisol-mediated regulation of adipogenesis and adipokine production 135

Certain blockbuster obesity drugs will be available for as little as $149 per month and more Medicare enrollees will have access to them under two deals announced Thursday by the Trump administration

In summary, this dual mechanism addresses the fundamental lipid dysregulation in MASLD by restoring the balance between lipid synthesis and degradation within the liver, thereby mitigating steatosis and its metabolic consequences (40, 43)