Describing herself as largely 'the lab rat' when she joined the diabetes team, Knudsen remembers she spent 'the first year in a cold room with three technicians to screen hundreds of thousands of compounds to see if they could wedge into the GLP-1 receptor and other targets of interest just snugly enough to stimulate insulin secretion.' To help speed up the screening process, Knudsen devised a method to test 96 candidates in one go instead of just one
Endogenous GLP-1 alters postprandial functional connectivity between homeostatic and reward-related brain regions involved in regulation of appetite in healthy lean males: a pilot study
Mechanistic work suggests that tri-agonist signaling may influence several components of glucose regulation, including insulin secretion pathways, hepatic glucose handling, and peripheral metabolic signaling
These improvements translate to reduced risk of heart attack, stroke, diabetes complications, liver failure, and premature death
Many patients successfully reduce to maintenance doses that significantly decrease costs
doi: 10.1210/jc.2018-00070 28 MarsoSPBainSCConsoliAEliaschewitzFGJodarELeiterLAet al