For HR teams, this matters because obesity, diabetes, heart disease, and related conditions can directly affect employee health, absenteeism, productivity, disability claims, and healthcare spending
Indirect Cardiac Effects Gastrointestinal side effects, particularly severe nausea, vomiting, and diarrhea, can lead to dehydration and electrolyte disturbances (hypokalemia, hypomagnesemia) that may affect cardiac rhythm
People with diabetes, particularly severe diabetes, tend to lose less weight with GLP-1s than people without diabetes, so microdosing is less likely to be as effective, though their dose should only be increased as they tolerate it. George said that in her professional opinion, microdosing is a potential option for patients with smaller amounts of weight to lose or as a bridge to start, or wean off, regular GLP-1 medications
People ask me all the time whether these compounded drugs are an option because of the cost and access, said Michael Blyumin, PharmD, an ambulatory clinical care pharmacist at Stanford Medicine
With the development of genetic testing technologies such as genome-wide association studies (GWAS) and next-generation sequencing (NGS), it has been discovered that approximately 127 locus abnormalities in the human genome are associated with the onset and progression of obesity [4] , as along with more than 550 monogenic mutations related to obesity [5]
Scientific American
