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They significantly increase the risk of serious stomach irritation and internal bleeding

Summary: GLP-1 receptor agonists can modestly reduce systolic blood pressure by approximately 24 mmHg, though they are not licensed specifically as antihypertensive medications in the UK

GI AEs caused treatment withdrawal in 13 cases

The use of GLP-1 medications in older adults has yet to be thoroughly studied in prospective clinical trials. Likewise, anyone with baseline osteopenia or osteoporosis may be at risk of a further decrease in bone density and an increased risk of falls and fractures, he added

Patients are encouraged to adopt a balanced diet rich in whole foods, engage in regular physical activity, and monitor their blood sugar levels consistently

This metabolic reprogramming presents a vulnerability of NEPC-differentiated CRPC that could be exploited therapeutically using GLP1R agonists given our observation that semaglutide markedly inhibits glycolytic function