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Pharmaceutical agents such as Cox-2 inhibitors, thalidomide, megestrol, medroxyprogesterone acetate, melatonin, and DCA, and supplemental nutrients or antioxidants from food [35], such as -3 poly-unsaturated fatty acids, vitamin C, vitamin D, vitamin E, -hydroxy--methylbutyrate (HMB) [36] and lycopene, represent potential anti-cachexia treatments that are being explored in clinical trials

Therefore, its true frequency is unknown

The alteration of the BBB is often marked by a degradation or shrinkage of ECs, alteration of the tight junction proteins connecting cells and modified transport mechanisms which all together impact greatly the BBB permeability

Haverstraw, NY 2/6/2016, Dr

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