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Specifically, when all other exposure variables were fixed at the 75th percentile, if the estimated single-exposure effect of a particular exposure variable increased or decreased compared to when it was fixed at the 25th percentile, then this was considered to indicate significant interactions between that variable and one or more other exposure variables, as described previously [45]

Restriction to milligram unit records: To ensure consistency, records were further restricted to those reporting cumulative doses in milligrams, yielding a final dataset of records