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Switching from retatrutide to cagrilintide is somewhat simpler because you are moving from a broader mechanism to a narrower one
The list includes: Addisons disease Amyloidosis Ankylosing spondylitis Coeliac disease Crohns disease Dermatomysositis Graves disease Guillain-Barre syndrome Hashimotos thyroiditis Multiple sclerosis (MS-like presentation/SACD (subacute combined degeneration)) Myasthenia gravis Pernicious anaemia/B12 deficiency Reactive arthritis Restless leg syndrome (RLS) Rheumatoid arthritis Sjogrens syndrome Systemic lupus erythematosus Type 1 diabetes Ulcerative colitis Many of the above conditions have overlapping symptoms, for example fatigue, general ill-feeling, joint pain and rash
The IRAP inhibitor 48 was the best inhibitor in a second series of bioisosteric diaminobenzoic acid inhibitors but was both less potent and selective as compared 47 (Papakyriakou et al., 2015)