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If you experience unexplained fatigue, kidney discomfort, or changes in urination while taking B12, it might be worth asking about genetic testing for these transport protein variations

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I've read it also helps if it's out if the fridge at room temp

Had a storage question before ordering and got a detailed, knowledgeable reply within the hour

These are symptoms that could indicate exhaustion in the form of B12 deficiency: Constant lack of energy or fatigue: tiredness after ushering in a good sleep

A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care