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The increased endothelial cell permeability is generated by TGF1 via SMAD3-dependent signaling, which upregulates matrix metalloproteinase-9 and downregulates claudin-5

In individuals with obesity or metabolic dysfunction, amylin signaling may be impaired

Xu Y, Crouch JH

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Each subcellular compartment in plants contains its own set of ROS-producing and ROS-scavenging pathways, but relatively little is known about how the different components in such compartmentalized systems are coordinated