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Emerging evidence suggests that glutamate excitotoxicity activates the RIP1/RIP3/MLKLmediated necroptotic pathway, inducing doseand timedependent necrotic damage in R28 cells and murine retinal RGCs

J Cell Physiol 234(12):2337923387

This combination is not FDA-approved, and no clinical trials have evaluated its safety or efficacy

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