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These two hormones are also elevated by stress, eating disorders, thyroid malfunction, diabetes, puberty, pregnancy, and liver and kidney failure.

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[DOI] [PubMed] [Google Scholar] 229.Arch JR

The research data accumulated through 20252026 have produced outcomes in preclinical and investigational contexts that exceed any prior pharmacological intervention of this class in the peer-reviewed literature

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Without ongoing B12 replacement, deficiency and symptoms will typically recur within months to years of discontinuation