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sometimes increases in HDL Liver : Improvements in fatty liver disease (reduced liver fat, improved liver enzymes) Cardiovascular Improvements : Blood Pressure : Significant reductions in systolic and diastolic blood pressure Cardiovascular Events : According to SELECT trial (semaglutide), 20% reduction in major cardiovascular events (heart attack, stroke, cardiovascular death) Heart Function : Improvements in cardiac structure and function markers Physical Function Improvements : Mobility : Improved ability to walk, climb stairs, engage in physical activities Joint Pain : Reduced knee, hip, and back pain from decreased weight-bearing stress Sleep : Improvements in sleep quality

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Chronic hyperglycemia leads to glucose auto-oxidation and excessive ROS production, overwhelming the antioxidant defense system and disrupting redox homeostasis [107,108,109,110,111]