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Curcumin demonstrates a substantial ability to interact with and modulate the regulation of various proteins, growth factors, transcription factors, enzymes, receptors, and other regulatory genes through both direct and indirect mechanisms (Goel et al., 2008

Evaluation of the brain tissue using immunohistochemistry and immunofluorescence showed an increase in both GFAP and Iba-1 positive cells in wild type mice treated with MPTP

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