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2017 Sep;40(3):60713

In addition to ghrelin losing its feeding effect in CB1 / animals, neuropeptide Y (NPY) has also been shown to lose its feeding effect in CB1 / animals (Poncelet et al., 2003)

C., Kanavaros, P

The more frequently you reach higher levels of drunk, the more your body compensates

This change is considered to result in lower extracellular GABA levels and the disruption of E/I balance toward predominately excitatory transmission, which was observed in another study that employed a rat model of prenatal VPA exposure (111)