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[DOI] [PubMed] [Google Scholar] 59.Morgan A., Mooney K., Mc Auley M

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Moreover, in vitro and in vivo models indicate that the activation of PPAR can inhibit HCC cell proliferation and tumor growth by inducing cell cycle arrest and apoptosis by means of the regulation of a panel of downstream effector molecules, such as p18, p21, p27, p53, and caspase-3/7 and caspase-8, respectively (Figure 4)