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Agonist-induced internalisation of the glucagon-like peptide-1 receptor is mediated by the Gq pathway

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Excessive dosages can lead to receptor desensitization (making the peptides less effective over time) and an increased risk of side effects

In glioblastoma, for instance, metformin has been observed to confer an increase in autophagy, particularly through the activation of the AMPK pathway

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