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Why GLP-1 Patches Cant Work (Yet) The real GLP-1 medications are big, complex molecules that just cant get through your skin effectively

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[1] [2] Short-chain fatty acids (primarily acetic, propionic, and butyric acids), which microganisms form in the intestines, bind to the FFAR2 and FFAR3 receptors on K cells and L cells to stimulate their respective production and secretion of GIP [3] and GLP-1

Back Tu, L (16 Oct 2023) 'Should insurance cover Wegovy, Ozempic and other weight-loss drugs?', Scientific American

And glucagon for increased energy expenditure and fat mobilization