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The melanocortin system consists of melanocyte-stimulating hormone (MSH), ACTH, five G-protein coupled receptors (MR1R-MR5R), and endogenous antagonists (Agouti & Agouti-related proteins)

Wakai K, Hayakawa N, Kojima M, Tamakoshi K, Watanabe Y, Suzuki K, Hashimoto S, Tokudome S, Toyoshima H, Ito Y, Tamakoshi A (2003) Smoking and colorectal cancer in a non-Western population: a prospective cohort study in Japan

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This activation tells our skin cells, called melanocytes, to make more melanin

10-Year follow-up of intensive glucose control in type 2 diabetes

Table 2 Clinical evidence of GLP-1R agonists for treating DPN