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10.1089/ars.2013.5236 [DOI] [PMC free article] [PubMed] [Google Scholar] Wang Q., Zhan S., Liu Y., Han F., Shi L., Han C., et al

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Hypoxia increases the deoxycytidine triphosphate (dCTP) level through the pentose phosphate pathway (PPP) via glucose metabolism and results in resistance to gemcitabine, a dCTP analog 87

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doi:10.1523/JNEUROSCI.2063-23.2024 26

How It Works PT141 is a synthetic analog of alphaMSH that activates melanocortin receptors (especially MC3R and MC4R) in the hypothalamus, modulating neural circuits involved in sexual desire, arousal, and reward