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Canalis E, Centrella M, Burch W, McCarthy TL

Of the six known IGFBPs, IGFBP-3 is by far the most common, accounting for around 80% of all bound IGF-1, typically forming a 150 kDa tri-molecular complex with it and the acid-labile subunit (ALS), known as the IGF-1-IGFBP-ALS complex [21]

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6c, d depicted that the ZFPG and ZFP + US treatments enhanced intracellular Cyt-C release compared with the Control, US, and ZFP groups, while the fluorescence intensity of the ZFPG + US group exhibited 4.12- and 2.24-fold higher than that in the ZFPG and ZFP + US groups respectively, indicating that mitochondria suffered the most severe oxidative damage after the ZFPG + US intervention

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