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Figure 1 Discussion To the best of our knowledge, this is the first clinical study in ME/CFS patients describing a novel administration route of vitamin B12

Moisture can promote hydrolysis (chemical breakdown due to water), and oxygen may contribute to oxidation in susceptible peptide sequences (Sigma-Aldrich, 2023b)

Smoking restricts blood flow to discs, making healing harder

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In addition, metallothionein 3 (MT3) can extract Cu 2 + from amyloid- or -synuclein complexes and facilitate its reduction to Cu + , a property attributed to its flexible N-terminal -domain containing a unique threonine insertion at position 5 that distinguishes MT3 from other metallothionein isoforms 195,196

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