Even safety data on TB-500 (synthetic TB4) is relatively scarce, with only a few studies reporting the potential side effects of its systemic application: In a 2010 study in 10 participants, TB4 caused occasional mild to moderate symptoms like headache and dizziness but no serious reactions or toxicities, even at doses up to 1260mg, administered daily for up to two weeks
Commun., 12 : 3985
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Several pathways have recently gained attention (Zhao et al., 2025
The first module gradually increased along pseudotime and was enriched in cell migration, cell junction remodeling, extracellular structure organization, and wound response
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