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So we have been doing that in our semaglutide trials, and we've just published the proteomics data from the step one and step two trials

The advancement of bone age relative to chronological age is an important consideration because bone age is 1 of the clinical criteria used to determine when treatment should cease

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Topiramate is usually initiated at a dose of 25 mg daily, taken in the morning, and increased by 25 mg each week as needed