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The peptide stimulates the activity of enzymes involved in ceramide biosynthesis, including serine palmitoyltransferase and ceramide synthase

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Recent evidence has shown that astrocytes are arranged in non-overlapping domains forming a syncytial network that may contact approximately 160.000 synapses, thus integrating neural activity with the vascular network [4,28]

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Using orthotopic murine breast cancer and melanoma that develop spontaneous LN metastases, we also showed that resection of TDLNs did not prevent ICB responses (63), which was attributed to the rerouting of antigen drainage to distant LNs

What is the Endothelium