fatty liver and glutathione Challenging the view of as a protector in disease: https://t.co/JgWnzwmRwH Xiang-Yu Liu @XiangYuLiu7 C. Ronald Kahn @diabetesmaster & team @harvardmed show glutathione depletion in the liver surprisingly prevents liver Glutathione disulfide sensitizes hepatocytes to

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Limitations Even though we strove to be as biologically detailed and unbiased as possible, we had to refine weakly constrained parameters due to limited available data and focus on the most relevant pathways and processes rather than simulating dynamics at the whole genome-scale

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Replicative endothelial cell senescence may lead to endothelial dysfunction by increasing the BH2/BH4 ratio induced by oxidative stress, reducing BH4 availability, and decreasing the expression of eNOS

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