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All the MC4R mutation carriers in the placebo-treated group were female (Extended Data Table 2)

The Melanocortin System Explained The melanocortin system is a complex neuroendocrine network that regulates multiple physiological processes, including: Sexual desire and arousal Erectile function Appetite and energy balance Skin pigmentation Blood pressure regulation Melanocortin receptors, particularly MC3R and MC4R, are highly expressed in the hypothalamus and central nervous system

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