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A Clinical Pathologist with FRCP credentials and NMC registration (UKMC Reg

Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo

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This pathway can be inhibited by the cell-survival signaling pathways mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K)/Akt (protein kinase B), which may protect the cells against the cytotoxic effects of VPA [210]