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Oral semaglutide requires a very specific environment in the stomach to be absorbed correctly, usually requiring an empty stomach with a small amount of plain water

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Branded GLP-1 drugs (Wegovy, Ozempic, Mounjaro) range $300$1,500/month uninsured

Semaglutide activates only the glucagon-like peptide-1 receptor, while tirzepatide activates both the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide receptor

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Interestingly, a subgroup analysis of the Thiazolidinediones Or Sulfonylureas Cardiovascular Accidents Intervention Trial (TOSCA.IT) suggested that even low doses of PIO can significantly improve liver steatosis and inflammation in patients with T2D independently of its blood glucose lowering effect [54]