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doi: 10.1186/s12937-016-0166-9 54 ZhangQWuYFeiX

Alves, Thiago Bruder-Nascimento Biochemical Pharmacology.2022

Its definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!)

Furthermore, all treatment combinations, except melatoninbetaine and GAbetaine, significantly ameliorated the induced changes in IL-10 and TNF- levels

Reputable manufacturers will often provide this information on their packaging or website

(2) loss of enzymatic activity leads to a shift to a cardiovascular pro-damaging axis of the RAAS involving higher levels of Ang II followed by reduced production of Ang(17) 30, 31